SARS coronavirus replicase proteins in pathogenesis
Identifieur interne : 000F03 ( Pmc/Checkpoint ); précédent : 000F02; suivant : 000F04SARS coronavirus replicase proteins in pathogenesis
Auteurs : Rachel L. Graham [États-Unis] ; Jennifer S. Sparks [États-Unis] ; Lance D. Eckerle [États-Unis] ; Amy C. Sims [États-Unis] ; Mark R. Denison [États-Unis]Source :
- Virus Research [ 0168-1702 ] ; 2007.
Abstract
Much progress has been made in understanding the role of structural and accessory proteins in the pathogenesis of severe acute respiratory syndrome coronavirus (SARS-CoV) infections. The SARS epidemic also brought new attention to the proteins translated from ORF1a and ORF1b of the input genome RNA, also known as the replicase/transcriptase gene. Evidence for change within the ORF1ab coding sequence during the SARS epidemic, as well as evidence from studies with other coronaviruses, indicates that it is likely that the ORF1ab proteins play roles in virus pathogenesis distinct from or in addition to functions directly involved in viral replication. Recent reverse genetic studies have confirmed that proteins of ORF1ab may be involved in cellular signaling and modification of cellular gene expression, as well as virulence by mechanisms yet to be determined. Thus, the evolution of the ORF1ab proteins may be determined as much by issues of host range and virulence as they are by specific requirements for intracellular replication.
Url:
DOI: 10.1016/j.virusres.2007.02.017
PubMed: 17397959
PubMed Central: 2637536
Affiliations:
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Graham</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3">The Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Sparks, Jennifer S" sort="Sparks, Jennifer S" uniqKey="Sparks J" first="Jennifer S." last="Sparks">Jennifer S. 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Eckerle</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3">The Elizabeth B. 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Sims</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R." last="Denison">Mark R. Denison</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3">The Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><series><title level="j">Virus Research</title><idno type="ISSN">0168-1702</idno><idno type="eISSN">1872-7492</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Much progress has been made in understanding the role of structural and accessory proteins in the pathogenesis of severe acute respiratory syndrome coronavirus (SARS-CoV) infections. The SARS epidemic also brought new attention to the proteins translated from ORF1a and ORF1b of the input genome RNA, also known as the replicase/transcriptase gene. Evidence for change within the ORF1ab coding sequence during the SARS epidemic, as well as evidence from studies with other coronaviruses, indicates that it is likely that the ORF1ab proteins play roles in virus pathogenesis distinct from or in addition to functions directly involved in viral replication. Recent reverse genetic studies have confirmed that proteins of ORF1ab may be involved in cellular signaling and modification of cellular gene expression, as well as virulence by mechanisms yet to be determined. Thus, the evolution of the ORF1ab proteins may be determined as much by issues of host range and virulence as they are by specific requirements for intracellular replication.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Virus Res</journal-id><journal-id journal-id-type="iso-abbrev">Virus Res</journal-id><journal-title-group><journal-title>Virus Research</journal-title></journal-title-group><issn pub-type="ppub">0168-1702</issn><issn pub-type="epub">1872-7492</issn><publisher><publisher-name>Published by Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17397959</article-id><article-id pub-id-type="pmc">2637536</article-id><article-id pub-id-type="publisher-id">S0168-1702(07)00057-3</article-id><article-id pub-id-type="doi">10.1016/j.virusres.2007.02.017</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>SARS coronavirus replicase proteins in pathogenesis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Graham</surname><given-names>Rachel L.</given-names></name><xref rid="aff1" ref-type="aff">a</xref><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Sparks</surname><given-names>Jennifer S.</given-names></name><xref rid="aff2" ref-type="aff">b</xref><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Eckerle</surname><given-names>Lance D.</given-names></name><xref rid="aff1" ref-type="aff">a</xref><xref rid="aff2" ref-type="aff">b</xref><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Sims</surname><given-names>Amy C.</given-names></name><xref rid="aff4" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Denison</surname><given-names>Mark R.</given-names></name><email>mark.denison@vanderbilt.edu</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="aff2" ref-type="aff">b</xref><xref rid="aff3" ref-type="aff">c</xref><xref rid="cor1" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States</aff><aff id="aff2"><label>b</label>Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States</aff><aff id="aff3"><label>c</label>The Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, United States</aff><aff id="aff4"><label>d</label>Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, United States</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author at: 1161 21st Ave S, D6217 MCN, Nashville, TN 37232, United States. Tel.: +1 615 343 9881; fax: +1 615 343 9723. <email>mark.denison@vanderbilt.edu</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>30</day><month>3</month><year>2007</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>4</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>30</day><month>3</month><year>2007</year></pub-date><volume>133</volume><issue>1</issue><fpage>88</fpage><lpage>100</lpage><permissions><copyright-statement>Copyright © 2007 Published by Elsevier B.V.</copyright-statement><copyright-year>2007</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract><p>Much progress has been made in understanding the role of structural and accessory proteins in the pathogenesis of severe acute respiratory syndrome coronavirus (SARS-CoV) infections. The SARS epidemic also brought new attention to the proteins translated from ORF1a and ORF1b of the input genome RNA, also known as the replicase/transcriptase gene. Evidence for change within the ORF1ab coding sequence during the SARS epidemic, as well as evidence from studies with other coronaviruses, indicates that it is likely that the ORF1ab proteins play roles in virus pathogenesis distinct from or in addition to functions directly involved in viral replication. Recent reverse genetic studies have confirmed that proteins of ORF1ab may be involved in cellular signaling and modification of cellular gene expression, as well as virulence by mechanisms yet to be determined. Thus, the evolution of the ORF1ab proteins may be determined as much by issues of host range and virulence as they are by specific requirements for intracellular replication.</p></abstract><kwd-group><title>Keywords</title><kwd>SARS coronavirus</kwd><kwd>SARS-CoV</kwd><kwd>Replication</kwd><kwd>Pathogenesis</kwd><kwd>Reverse genetics</kwd><kwd>Protein processing</kwd><kwd>Temperature-sensitive mutants</kwd><kwd>ts mutants</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Graham, Rachel L" sort="Graham, Rachel L" uniqKey="Graham R" first="Rachel L." last="Graham">Rachel L. Graham</name></region><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R." last="Denison">Mark R. Denison</name><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R." last="Denison">Mark R. Denison</name><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R." last="Denison">Mark R. Denison</name><name sortKey="Eckerle, Lance D" sort="Eckerle, Lance D" uniqKey="Eckerle L" first="Lance D." last="Eckerle">Lance D. Eckerle</name><name sortKey="Eckerle, Lance D" sort="Eckerle, Lance D" uniqKey="Eckerle L" first="Lance D." last="Eckerle">Lance D. Eckerle</name><name sortKey="Eckerle, Lance D" sort="Eckerle, Lance D" uniqKey="Eckerle L" first="Lance D." last="Eckerle">Lance D. Eckerle</name><name sortKey="Graham, Rachel L" sort="Graham, Rachel L" uniqKey="Graham R" first="Rachel L." last="Graham">Rachel L. Graham</name><name sortKey="Sims, Amy C" sort="Sims, Amy C" uniqKey="Sims A" first="Amy C." last="Sims">Amy C. Sims</name><name sortKey="Sparks, Jennifer S" sort="Sparks, Jennifer S" uniqKey="Sparks J" first="Jennifer S." last="Sparks">Jennifer S. Sparks</name><name sortKey="Sparks, Jennifer S" sort="Sparks, Jennifer S" uniqKey="Sparks J" first="Jennifer S." last="Sparks">Jennifer S. Sparks</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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